Dopamine Receptor Inhibitor

Dopamine Receptor Inhibitors (44):

Cat. No.	Product Name	Effect	Purity

HY-A0081

Fluphenazine dihydrochloride	Inhibitor	99.89%
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.

HY-U00096

Ansofaxine hydrochloride	Inhibitor	99.87%
Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC₅₀ values of 723, 491 and 763 nM, respectively.

HY-N0300

Tetrahydropalmatine	Inhibitor	99.65%
Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

HY-113468A

3-O-Methyldopa	Inhibitor	≥98.0%
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-B1110

Nomifensine	Inhibitor	98.93%
Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

HY-B1110A

Nomifensine maleate	Inhibitor	98.79%
Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

HY-113468AS

3-O-Methyldopa-d₃	Inhibitor	99.34%
3-O-Methyldopa-d₃ is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

HY-108510

Rimcazole dihydrochloride	Inhibitor	99.80%
Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.

HY-12751A

Trimethobenzamide hydrochloride	Inhibitor	99.92%
Trimethobenzamide hydrochloride is a blocker of the D₂ receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

HY-B1017

Molindone hydrochloride	Inhibitor	99.78%
Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.

HY-N5140

Bacopaside X	Inhibitor	99.94%
Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor.

HY-119468

Medifoxamine	Inhibitor	99.72%
Medifoxamine is a monoamine re-uptake inhibiting antidepressive agent which preferentially inhibits dopamine reuptake.

HY-W008610

GBR 12783	Inhibitor
GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [³H]dopamine uptake by rat and mice striatal synaptosomes with IC₅₀s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats.

HY-100143

Pentiapine	Inhibitor	99.74%
Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites.

HY-W401531S

(R)-3-O-Methyldopa-d₃	Inhibitor
(R)-3-O-Methyldopa-d₃ is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine[1][2].

HY-100968

GBR 12783 dihydrochloride	Inhibitor	99.14%
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [³H]dopamine uptake by rat and mice striatal synaptosomes with IC₅₀s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

HY-106587A

Octoclothepin maleate salt	Inhibitor
Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents.

HY-W016388

9-Fluorenol	Inhibitor	99.40%
9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC₅₀ value of 9 µM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.

HY-N7512

Asimilobine	Inhibitor
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

HY-W152604

Cyclo(glycyl-L-leucyl)	Inhibitor
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias.

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